Here are the five best Vayne supports you should be playing in the 2025 season to increase your chances of victory with the ADC champion.

Best Vayne supports in LoL

Vayne has always been one of the flashiest marksmen in the game. Despite having some of the weakest laning phase and auto attack range in the game, she has one of the highest late-game carry potential in her class and unmatchable mobility. If you’re into the montage plays or 1v9 carry performances, this is one of the champions you should be playing.

Over the years, however, the bot lane has become a tough playing field for the champion, who was often punished in her weak early game. With the changes to snowballing in the game, Vayne now has more time to scale and room to play, although you still need to rely on strong support combinations to get through the laning phase. For this reason, here are five picks you can always play, which should enable her and become the menace to take over games.

Best Vayne Supports in 2025

  1. Lulu
  2. Nami
  3. Milio
  4. Karma
  5. Soraka

Lulu – The undisputed best support for Vayne

  • Shields and Polymorph give Vayne the tools to duel anyone
  • Wild Growth buys time in clutch moments
  • Enhances Vayne’s DPS so she wins extended fights

Lulu is hands down the best support for Vayne. The synergy is simple: Vayne wants time to auto-attack, and Lulu gives her exactly that. With Polymorph shutting down divers and Wild Growth giving her a massive buffer in teamfights, Lulu ensures Vayne can survive most of the incoming burst damage while still dealing damage. This is a consistent duo that works out across all levels of play and you should be playing them together whenever you get the chance in ranked play.

lulu vayne best supports
Image Credit: Riot Games

Nami – The meta pick

  • Tidecaller’s Blessing makes Vayne’s short trades better in the laning phase
  • Sustain offsets her weak laning phase
  • Good crowd controls from Nami’s Q and ultimate

Despite Lulu being the best, that bot lane duo is often considered weak early on and can be heavily exploited in specific matchups. As an alternative, you can consider Nami in the current meta, given her power among the support pool. Nami can make Vayne’s laning phase a bit easier to digest, increasing her chances of coming out in a favorable position and hitting her power spikes faster. The champion is also quite easy to play, meaning it doesn’t require much time to master.

Milio – the best kiting duo

  • Extends Vayne’s range so she can kite better
  • Good shields early on and healing later
  • Can cleanse crowd controls with ultimate

If you are a passive player and prefer to stick to something less aggressive, Milio is also another champion you can consider playing with Vayne. His greatest strength comes from his ability to increase her short attack range with Cozy Campfire (W) while also bringing good shields and heals from E and ultimate. He also grants additional damage thanks to the passive.

Karma – The kiting combo

  • The strongest early game enchanter
  • Shields and movement speed make the kiting job easy for Vayne
  • Trading better lane power for weaker late game

While she is usually not a go-to support duo pick, Karma is currently in a strong state and pairs quite well with Vayne. The Ionian support can create good lane pressure with her poke, making it easier for Vayne to scale up without being bullied. Additionally, she can consistently cast shields that give good movement speed, allowing her to consistently reposition in skirmishes and fights. It’s also a good idea to deny it to the opponents, who often want to go for lane bullies to counter Vayne.

karma cailtyn best supports
Image Credit: Riot Games

Soraka – Infinite sustain

  • Constant heals should keep Vayne healthy in the laning phase
  • The global ultimate can be a game-changer in nasty situations
  • One of the weakest trading bot lane duos

You’ve probably realized that enchanters are the ideal picks for a carry like Vayne so Soraka is also a logical option that works well. While she doesn’t fix Vayne’s poor early game, she makes up for it by bringing one of the best sustains in the game. Soraka’s healings will likely negate most of the incoming damage Vayne receives later on, turning the ADC into an unkillable 1v9 machine. And even if Vayne gets caught, the opponents will likely have to burn more abilities than necessary to deplete her health bar.